Why Test?

Hyperglycemia: Glycemic Control Reduces Diabetes Complications

The American Diabetes Association (ADA) has set glucose and A1C targets to help monitor glycemic control and reduce diabetes related outcomes.

Current Glycemic Control Testing Has Its Limitations

A periodic finger stick glucose is not always reliably timed or performed, and may yield inaccurate results.3,4

A quarterly or bi-annual A1C glucose average is a lagging indicator of glycemic control and is incapable of detecting recent hyperglycemia and glycemic variability. Up to 40% of patients considered by A1C to be in “good control” may be experiencing postprandial hyperglycemia and glycemic variability.5,6 Over 15% of A1C results can be affected by physiological and pharmacological factors associated with the patient’s hemoglobin. The estimated blood glucose range for an A1C of 7% is 123 – 185 mg/dL.6

The Utility of the GlycoMark Test

ABNORMAL GlycoMark results identify patients with recent hyperglycemic excursions that are not evident with A1C.

• In comparing two patients with similar “good” A1Cs of 7.4%, the glycemic profiles are quite different.  Without the GlycoMark test, these patients might receive the same treatment and ongoing management.
• By incorporating the GlycoMark test, patients with a low GlycoMark test can be more closely and individually managed to reduce glycemic variability and improve their A1C.

INCREASING or DECREASING GlycoMark results reveal changes in glycemic control (improving or worsening).

• Allows for timely detection of changes in glycemic control associated with health, lifestyle and/or treatment modifications
• Used in conjunction with A1C to help guide treatment strategies and get patients to goal

Multiple studies independently link 1,5-AG with diabetes complications and outcomes.

Refer to the GlycoMark test package insert for additional information.

Note:

• The GlycoMark test is not affected by hemoglobinopathies, such as anemias, sickle cell disease or malaria,  because it is not a hemoglobin glycosylation marker like A1c.
• The GlycoMark test has been tested and found to be unaffected by hemoglobin (125 mg/dL), triglycerides (1153 mg/dL), bilirubin (40 mg/dL), glucose (1000 mg/dL),  maltose (500 mg/dL), ascorbic acid (25 mg/dL), uric acid (20 mg/dL), urea (20 mg/dL) and creatinine (10 mg/dL).

References:
¹American Diabetes Association. Diabetes Care 2015 Jan; 38(Supplement 1): S33-S40.
²Stratton IM, et al. BMJ. 2000 Aug 12;321(7258):405-12.
³Erbach M, et al. J Diabetes Sci Technol. 2016;10:1161-1168.
⁴Klonoff DC, et al. J Diabetes Sci Technol. 2011;5:1529-1548.
⁵Erlinger TP, Branca FL. Diabetes Care. 2001 Oct;24(10):1734-8.
⁶Bonora E, et al. Diabetologia. 2006 May;49(5):846-54.
⁷Dungan KM, et al. Diabetes Care 2006 Jun; 29(6): 1214-1219.
⁸Selvin E, et al. Clin Chem. 2014 Nov; 60(11): 1409–1418.
⁹Selvin E, et al. Diabetes 2016;65:201–208.
¹⁰Lee AK, et al. Diabetes Care 2017 Dec; 40(12): 1661-1667.
¹¹Rawlings AM, et al. Diabetes Care 2017 Jul; 40(7): 879-886.
¹²Nowak N, et al. Diabetologia 2013 Apr;56(4): 709–713.